In our latest question and answer, the pharmacist discusses the potential interaction in between Nyquil and melatonin.

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At a glance

taking NyQuil products, which contain the sedating antihistamine doxylamine, v melatonin can increase sedation and have additive CNS depressant effects.



There room a range of Nyquil commodities currently easily accessible over-the-counter,but most contain the following energetic ingredients:


Acetaminophen is because that pain management, dextromethorphanis for sneeze suppression, and also doxylamine is one antihistamine offered for sleep,runny nose, sneezing, itching, and also watery eyes.

Doxylamine is the ingredient in NyQuil that causes sedation as it is a first-generation antihistamine (similar come Benadryl).

Melatonin is naturally developed in our body to help regulate the sleep-wake cycle however is additionally commonly offered over the counter supplement to aid treat insomnia.

Online interaction checkers will regularly list NyQuil products and also melatonin as having an interaction with one an additional due come theiradditive effects.

This is since both doxylamine and melatonin develop sedation and also have mild CNS (central worried system) depressant properties. As result of this, that isrecommended using these products along with caution.


There haven"t been any studies that have specifically evaluate the threat of making use of NyQuil and melatonin together, but based upon their known effects, taking both can potentially cause additive sedation, sleep-relateddisturbances, CNS and respiratory depression.<1>

If taking these two together, it is essential to report any type of unusual sleep-related behaviors and one that theproducts might need to it is in discontinued.

There may be situations where both space recommended, prefer if you are using melatonin to assist treat "jet lag" (i.e. Do the efforts to gain your sleep-wake cycle ago on your regular schedule) however you must talk to her doctor first before combining.<2>

How Antihistamines Work

Antihistamines tie to histamine receptors the are found in the nose, lungs, eyes, and skin there is no activating the histamine response. By binding and an altering the form of the histamine receptor, antihistamines inhibit histamine native binding and creating that is response.<3>

First-generation antihistamines, choose doxylamine, are not selective for any details tissue and also are therefore more likely to cause drowsiness. Both doxylamine and diphenhydramine (Benadryl) are used as one over-the-counter sleep aid in enhancement to its various other uses.

Over time, the body becomes tolerant come the sedative results of antihistamines and these usually should not be relied upon together a sleep aid for lengthy term use.

How Melatonin Works

Melatonin is naturally produced by the pineal gland and also is known to be crucial in the circadian rhythm and sleep cycle.<4>

Melatonin production is believed to be stimulated by dark and inhibited by light. The is thought that melatonin helps reset the human body to its normal rhythm, particularly in patients experiencing jet-lag or who job-related the night shift.

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In the hospital setting, melatonin is occasionally used in the intensive treatment unit to assist promote common circadian rhythms, alleviate delirium and also the need for sedatives.